This may be my favorite type of project. Given an accepted manuscript, I'm asked to come up with designs that might be chosen by the journal's editors to represent the article on the cover of that issue. The risk is that they may not choose to use it, so I will come up with a few different designs (will post a second version soon). The article is about how a small library of electrophilic triazole urea-based compounds, made with the help of click chemistry, revealed three very specific inhibitors of three different serine hydrolases. One even showed great potency and selectivity in mice. It's pretty remarkable considering how similarly these hydrolases look and act, but nothing a little clever chemistry couldn't overcome.