Let them have color!

This particular client is not a fan of color. I think that if there were glasses available that allowed the viewer to see the world in grayscale, she would be first in line to purchase a pair. In black. She was, in fact, the inspiration for the series of eucalyptus tree paintings I did. But her students have spoken, and they want color. So after a very long week I was really looking forward to sitting down and playing around with this. The website has a maroon and gold theme, based on the school colors, so I took the maroon and incorporated its split complement colors in various permutations. For some reason I thought it would be more fun to present some options in this Warhol screenprint-inspired format. If Marilyn Monroe were a cysteine-reactive protein.

Mmmm.... self-promotion

I am putting a full-page ad in the Association of Medical Illustrators' Medical Illustration Source Book, where many of the science illustrators that I admire also advertise. This morning I worked on the layout for it, but I am stuck. Little help, please?

Sili gets the last laugh

Okay, I know I said the chemistry poetry book was done. But now that we've gotten the proofs and realize that some little things will need to be changed, I am considering replacing one of the illustrations. This is just a rough sketch I did today to get some ideas down. The poem, written of course by Mala Radhakrishnan, is about an atom of Silicon named Sili, who is teased relentlessly in school because, being neither metal nor non-metal, he was having trouble fitting in.

"

Though like a metal (it was quite shiny),

Its conductivity was tiny.

Its band gap was too far from little,

And unlike metals, ’twas rather brittle.

 

It clutched electrons way too tightly,

So metals would tease it daily and nightly.

Yet nons would also jeer and nettle,

“You dress and look just like a metal!”


What pain ’cause it did not conform,

No box for it to check on forms.

Few others could know the lonely void

That it lived as a “metalloid.”

"

Of course, he eventually proves to be very useful indeed, and everyone loves him...

"

And nowadays, sili’s still lionized.

Its band gap equals a perfect size

To dope with nearby brothers and sisters

And make computers from transistors.

 

As if its utility has not yet impressed us,

It’s also in quartz and in glass and asbestos.

And silicon’s used in chemical plants

For lubricants and breast implants.

 

Sili, its fourteen electrons so strong,

Proved all of its skeptical peers to be wrong

When it managed to move all the way out to Cali

And founded its very own aptly-named valley.

"

With this illustration I tried to incorporate as many silicon-containing materials as I could, including a computer, a quartz watch, solar panels, a car, glass, bluetooth device, and some, shall we say, augmentation. (Obviously I'm talking about Sili's calves.)

Couldn't help but notice...

I have an illustration project right now that involves a model of the P-glycoprotein, a molecular pump that non-specifically transports small hydrophobic molecules out of cells. It's presumably there to keep toxins out of our cells, but it's also a pain in the neck when therapeutic drugs meant to be delivered to the cell are pumped out of it.  Anyway, I couldn't help but notice that a model of a similar ABC transporter, at a certain angle, looks decidedly bunny-like, so I just had to go with it.

You can make your own molecular bunny! The pdb accession code is 2HYD. I used the molecular visualization program VMD*. Get the surface model into this perspective and highlight residues 10 to 45 for the left ear, 155 to 190 for the right ear, 331 for the nose, 217 to 219 for the left eye, and 326 to 328 for the right eye. I won't lie to you. I made the mouth in photoshop. I don't expect anyone other than myself to waste perfectly good time to make this very creepy looking rabbit, but you just never know.

*Humphrey, W., Dalke, A. and Schulten, K., "VMD - Visual Molecular Dynamics" J. Molec. Graphics 1996, 14.1, 33-38.

Needlestack

Needing a break from making lecture slides now and then, I'm excited to have this project to work on. I first posted a rough(er) version of it here on December 14th. My very good friend has just embarked on her independent academic career in a top-ranked chemistry department, and of course needs some graphics for her website. In her lab they use fancy mass spectrometry techniques to identify enzymes in their active state within complex biological systems - the proverbial needle in the haystack. A needle in a haystack could be found with a strong enough magnet though. Their problem is much much harder.  It's more like finding a needle in a needlestack. Wait, no, that would be easy. How about finding a specific needle in a needlestack? There we go. Let's say they want to find the needle in the needlestack that only sews up toe holes on pink sweatsocks, for example, and of those, only the ones that are currently in business. So they throw in a holey pink sweatsock. They wait for the needle to start sewing, and then pull out the sock. In the illustration above, an enzyme's reactive cysteine (needle) has been trapped upon reacting with (sewing) an iodoacetimide (pink sock). In the interest of full disclosure, I personally have as much experience with activity-based protein profiling as I do with sewing (that being none), so I may not be the most qualified to make this analogy.

Mapping out Chemistry Lectures

Well, it's not chemistry poetry, but if I do my job well enough I should be increasing the market for it. I'm using Apple's Keynote to make these, but was inspired by the Prezi software, which allows you to navigate around a map like this and pan in and out to different locations. I haven't decided exactly how I'll present it, but the non-linearity of it helps me organize my thoughts. Deciding where to draw connections gets me to ask myself questions that I otherwise probably wouldn't. Now I think that "Periodic Table Organization" is taking up way too much real estate, and I should just toss it and put the "properties" node in the middle. Yeesh, that's going to get messy. Okay, back to it. Classes start in a week and a half.

The futility of advertising in my comments section

You may have noticed that people or computers have been using the comments sections of this sketch blog as spots for advertisement. I do appreciate the additional traffic that this could lead to. I imagine that shoppers searching for fur-lined moon boots or the fashions favored by Jon Gosselin of Jon & Kate Plus Eight fame might fortuitously stumble across my website. I imagine them exclaiming, "What's this now? You mean I can get high-quality scientific graphics from an illustrator with a dozen years of research experience? Well for goodness sake, get me to the contact page at once!" However, to be fair, I feel obligated to admit that my readership is actually quite small. To illustrate this, I made the following 3D infographic. This should make it clear that it isn't really worth the time it takes to place these ads here.

Chemistry Poetry Book is Finished!

In the past four days, I've left the apartment for a total of exactly one hour. After lunch yesterday, having hit the rather low point of eating the only thing I could find - Quaker Oats - out of the saucepan I made it in, I decided a trip to the store and a bit of fresh air would be good. The reason for my apparent seclusion is that Mala and I have been putting the finishing touches on the chemistry poetry book so we can send it off for publication soon. It is just amazing how long that can take. But now it's in good shape, and here is one more illustration. Please refrain from telling me if you see a mistake. The following is an excerpt from the poem (by Mala Radhakrishnan) that it illustrates. (Note: The poem never explicitly states which base she is, so I decided to make her lithium hydroxide, thus giving her a somewhat proportional head. Never mind that the indicator strip is nowhere near to scale...)

She looked in the mirror and stared at her face.
It just wasn’t easy being a base.
All that she wanted: a shoulder to cry on
And ways to remove her hydroxide ion.

...

Her molecular orbitals so unattractive,
Her hydroxide ion was not yet reactive.
All of her neighbors, they managed to hate her,
Except for her one friend, an indicator.

This friend would say, “It’s tough knowing you.
Wherever we go, you keep me so blue.

...

'Zyme 'Zine

Years ago while I was living in Cambridge, MA, a philosophy graduate student at Tufts told me that I should start a magazine about enzymes. “You could call it The ‘Zyme ‘Zine.” he said. He had an enormous handlebar moustache and his name was Gabriel Love, which made me think I should hear him out. I was reminded of the ‘zyme ‘zine idea while reading “Art of McSweeney’s”, a wonderful Christmas gift from my brother-in-law and sister-in-law.  But I was too busy to start a magazine then, and I’m too busy now.  I wish someone would do it though. It could be dedicated to the wonder of those amazing proteinaceous catalysts. I’ll volunteer to do the cover designs (see mock-up above), and I could submit a story about the enzyme that got me a Ph.D. – a glycosyltransferase with the unlikely habit of transferring two mannose residues with distinct linkage specificity.  McEnzyme's is not just a play on McSweeney's. McEnzyme is actually the name of a dog that belongs to a brilliant and famous enzymologist who recently asked me, “So this is what you’re doing with your life?”



Kylanders

Here's something I put together as a bonus Christmas present for husband Kyle. It's a mish-mash of logos from his three favorite professional sports teams and proof that he is no fair-weather fan. None of these teams have been particularly inspiring of late, so I made this as a celebration of the loyal fan.

(Just to be clear, this is not for sale or distribution. It was made from images owned by the NY Islanders, NY Mets, and Dallas Cowboys)

 

O'Reilly Law Firm - Help when you are hurt

This is a placeholder graphic I threw together today for my Dad's website, which I've been putting together for him while I'm home for a visit. Eventually we'll get some photos but I didn't want to leave it so sparse in the meantime. He is a workers compensation lawyer in Indiana, and recently decided it was time to expand his advertising beyond the yellow pages. Not much of an early adopter, he at one point on Christmas Eve looked around at a house full of people on iPhones, Droids, and laptops, and said, with a sigh, "If you'll all excuse me I'm going outside to club a dinosaur."

OSA holiday party

Knocked off a little early over here today for the first annual O'Reilly Science Art holiday party.  While it was undoubtedly a festive affair full of holiday cheer (thank you Bear Republic), it wasn't exactly like the holiday parties I'm used to. As it turns out, potlucks and white elephant gift exchanges really work better with more than one person (though uncannily I still somehow wound up with scented candles like I do every year). On the other hand, my jokes were unanimously funny and I did not have to wear shoes.

Scientists tackle graphic design

I spent the better part of the morning today poring over the proofs for an article on some of my postdoc work that was recently accepted into the Journal of Immunology. This is Figure 7. It may not look like much, but that is what I think makes it remarkable. Thanks to my former postdoc advisor, Jim Paulson, who sent me back to the drawing board over and over and over and over again, this simple little diagram describes three different complicated-to-explain assays that I did to ultimately demonstrate that a certain cell surface receptor is able to recycle back to the cell surface after being internalized by the cell. This was by far the best training in design that I have ever had, and I just wanted to post this as a little reminder to myself.

Doodling

Just having some fun brainstorming/doodling on a new project I have for a good friend of mine. She and I had too much fun celebrating with the newly minted Dr. Angelyn Larkin over the weekend to get much work done on it though. Congratulations Angelyn!

A new chapter in icons

The fourteen chapters of Mala Radhakrishnan's chemistry poetry book have titles like Gases, States of Matter and Intermolecular Forces, Solubility and Equilibrium, Periodic Trends, etc. I designed these simple icons to introduce new chapters along with the titles. Obviously we are in the late stages of getting it together, and it should be available  in early 2011!